Atypical Fibroxanthoma FAQs

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What is atypical fibroxanthoma? »

Atypical Fibroxanthoma

When asking a person about the different types of skin cancer, you would be hard pressed to find anyone other than a dermatologist who put atypical fibroxanthoma on the list. Atypical fibroxanthoma is a type of skin cancer and is known for its dermal spindle-cell tumors. These occur on the head and neck generally on older people who have had a lot of sun damage.

The reason for its lack of being in the skin cancer conversation is that atypical fibroxanthoma is quite rare, accounting for less than 0.2% of all skin cancers. Plus, it is generally benign.

 The development of atypical fibroxanthoma is associated with aging, long-term ultraviolet radiation exposure from the sun, and frequent x-ray radiation. Both forms of radiation can cause the abnormal growth of atypical spindle cells.

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What are the demographics of people who get atypical Fibroxanthoma?

This rare form of skin cancer affects both sexes equally. It forms as a result of UV radiation or x-ray radiation. The mean age at diagnosis is 69 years. 

An even more rare form of AFX occurs in younger patients on parts of the body that are not normally overexposed to the sun. There is also an increased incidence of AFX in patients with acquired immune deficiency syndrome (AIDS) and in patients who are immunosuppressed, for instance after organ transplantation.

How aggressive is Atypical Fibroxanthoma?»

This form of skin cancer is generally benign, although the tumors can be quite unsightly. Because it is a much less common, and familiar, form of skin cancer, atypical fibroxanthoma (AFX) can be misdiagnosed as other forms of skin cancer. This can lead to unnecessary extensive surgery and radiation. This can happen because AFX can arise rapidly, over just a few weeks or months, in skin in the areas common to all forms of skin cancer. While its growth rate is rapid, AFX is not overly aggressive.

What are the symptoms of atypical fibroxanthoma? »

Atypical fibroxanthoma lesions typically appear in areas that have received excessive sun exposure over the person’s lifetime. These are the usual areas — scalp, cheeks, nose, ears, back of the neck, and the shoulders. They can also occur in areas where the patient may have received radiotherapy treatment that may have damaged the skin. These are the characteristics of atypical fibroxanthoma lesions:

  • Usually, these form a single tumor.
  • These are red, juicy, dome-shaped nodules that can bleed, crust, or are ulcerated.
  • Tumors start as small nodules but grow quickly over the next 6 months.
  • Tumors can grow to the size of 2-3 centimeters.
  • Occurrence is four times as likely on the head and neck as other body areas.

What causes atypical fibroxanthoma? »

Atypical fibroxanthoma is associated with prolonged years of sun exposure, aging, and possibly x-ray radiation exposure. Both UV radiation and x-ray radiation can cause abnormal growth of atypical spindle cells, which lead to these growths.

How is atypical fibroxanthoma treated? »

Treatment of atypical fibroxanthoma is complete surgical excision by a dermatologist. Small AFX lesions can be removed by curettage. Mohs micrographic surgery is becoming the preferred treatment for large or recurrent lesions because of its ability to remove the least amount of healthy tissue and its high success rates for complete, permanent removal.

The lesions grow quickly and can become about 2-3 centimeters in size. Because they occur on the head, face, neck, and shoulders, patients want to have them removed.

What is the cure rate for atypical fibroxanthoma? »

Atypical fibroxanthoma rarely recurs after complete excision with clear margins, making it virtually 100 percent cure rate. The key to not developing additional growths is to limit sun exposure to the areas of the head and back of the neck.

Start Your Treatment For Atypical Fibroxanthoma Today »

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American Society for Mohs Surgery
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